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Yes, people with degenerative arthritis can load magazines with the correct Uplula.

It appears that the gun does not fit your hand. Would you walk 5 miles in shoes that don't fit? Go to a gun store and handle as many different brands of 380's (if that's your preference) that you can. Find what feels natural and comfortable, then go to a range and shoot the brands and models that were comfortable. I'll bet your target acquisition and shot groups will be better and tighter. That will also reduce the sore hands.