I'm not a lady, but I am in touch with my feminine side.
If you can determine what portion of the grip is causing the soreness, you might be able to add a Houge grip sleeve that would help cushion the grip, as well as make it a little larger in your hand.
http://www.hoguestore.com/index.php?mai ... ts_id=7332" onclick="window.open(this.href);return false;
If your hand is getting sore from the bottom of the grip edge, you might add a Pearce Grip Extension to add it to the magazines
http://www.pearcegrip.com/Products/Ruger" onclick="window.open(this.href);return false;